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The pharmacokinetics of sildenafil citrate in patients with seriously afflicted hepatic social function (Child-Pugh Separate C) deliver non been studied [see DOSAGE AND ADMINISTRATION and Use In Specific Populations]. Later either viva voce or intravenous administration, sildenafil citrate is excreted as metabolites preponderantly in the faecal matter (around 80% of administered viva dose) and to a lesser extent in the pee (or so 13% of the administered viva voce dose). Similar values for pharmacokinetic parameters were seen in normal volunteers and in the affected role population, victimisation a population pharmacokinetic border on. When VIAGRA 100 mg unwritten was co-administered with amlodipine, 5 mg or 10 mg oral, to hypertensive patients, the signify additional decrease on resistless rip hale was 8 mmHg pulsation and 7 mmHg pulse. In volunteers with internal organ disability (Child-Pugh Form Aand B), sildenafil citrate clearance was reduced, resulting in higher plasm exposureof Viagra (47% for C scoop and 85% for AUC). The pharmacokinetics ofsildenafil in patients with badly afflicted hepatic routine (Child-PughClass C) make non been deliberate.
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